The silent killer of cognitive speed. Learn how systemic inflammation crosses the blood-brain barrier to cause brain fog, depression, and slowed processing.
While acute inflammation is a healthy immune response to injury, Systemic Chronic Inflammation is a metabolic disaster for the brain. It is the root cause of many “psychological” issues, including depression, brain fog, and fatigue.
The majority of your immune system resides in your gut.
Leaky Gut, Leaky Brain: When the gut lining is compromised (by processed food, alcohol, or stress), inflammatory cytokines enter the bloodstream. These cytokines cross the Blood-Brain Barrier and activate the brain’s immune cells (Microglia).
Sickness Behavior: Activated Microglia shut down dopamine production and serotonin pathways to force the body to rest. In a modern context, this feels like unexplainable lack of motivation or low mood.
Cognitive clarity often returns when you remove the inflammatory insult.
Elimination: Removing seed oils, refined sugars, and known allergens reduces the cytokine load.
Cold Therapy: Brief exposure to cold reduces systemic inflammation and increases norepinephrine.
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