MindLAB Neuroscience Neuroscience-based Life Coaching logo featuring a polygonal brain icon.

What are the Causes of Depression?

a woman sitting on a couch wuth her head in. her hands who is depressed and wondering what causes depression


Depression is a complex and often misunderstood mental health condition that affects millions of people worldwide. In this article, we will explore the most common causes of depression and how they contribute to this condition. Depression is caused by a combination of factors, including genetics, brain chemistry, life events, and environmental factors. However, it can be challenging to determine the specific triggers for each individual.

Genetics and Brain Chemistry in depression:

A family history of depression can make individuals more susceptible to the condition. Antidepressants alter brain chemistry, but depression is a multifaceted condition influenced by both genetic and environmental factors.

Life Events:

Traumatic life events, such as job loss or relationship breakdown, can trigger depression. Positive life changes, such as getting married, can also be stressful. How we cope with these events, and the support we have, can determine whether low mood becomes depression.

Childhood Experiences and depression:

Childhood trauma, such as abuse or neglect, can increase the risk of depression later in life. Multiple smaller events can also impact an individual’s vulnerability more than a single major event..

Comorbid Mental Health Problems:

Struggling with another mental health condition, such as anxiety or PTSD, can trigger depression. Managing symptoms of one condition can be challenging and lead to stress and low mood.

Physical Health Problems and depression:

Chronic physical health conditions or significant lifestyle changes can contribute to depression. Certain physical health problems, such as those affecting the brain and nervous system or sleep problems, can cause depression.

Medication, Recreational Drugs, Alcohol:

Certain medications, alcohol, and recreational drugs can all lead to depression. It’s crucial to speak to a doctor if experiencing depression while taking medication. Alcohol and drugs can temporarily provide escape but worsen depression long-term.

Sleep, Diet, and Exercise:

Sleep, diet, and exercise all play a role in depression. A poor diet, lack of sleep, and exercise can make it harder to cope with challenging situations, leading to a low mood. Taking care of physical health can positively impact mental health and vulnerability to depression.


Depression is a complex condition caused by a combination of genetic, environmental, and lifestyle factors. By understanding the causes of depression, individuals can develop effective prevention and treatment strategies. Seeking help from a professional who is an expert in neuroscience-based counseling is crucial if you experience symptoms of depression, as early intervention can absolutely lead to better outcomes. Remember, you are not alone, and MindLAB Neuroscience is available to help you manage and overcome depression. Permanently.

Share this post

Picture of Dr. Sydney Ceruto

Dr. Sydney Ceruto

A Pioneer in Neuroscience-Based Coaching

As the founder of MindLAB Neuroscience, Dr. Sydney Ceruto has been a leading force in integrating neuroscience into coaching and counseling for over two decades. With three master's degrees in psychology and two PhDs in behavioral and cognitive neuroscience, she is widely considered a top expert in her field.

Harnessing the power of neuroscience-based coaching, Dr. Ceruto's innovative approach focuses on neuroscience, neuroplasticity, and neural pathway rewiring to foster lasting positive change in mental health.

Dr. Ceruto holds esteemed memberships in the Forbes Executive Council, Positive Performance Alliance, Wharton Executive Education Program, the International Society of Female Professionals, and executive writing positions for Alternatives Watch, Brainz Magazine, and TED: Ideas Worth Spreading.

Dr. Ceruto's accomplishments include:

  • The 2022 CREA Award.
  • A lead research position at NYU Steinhardt.
  • Volunteer work with Covenant House and the National Alliance for Mental Health (NAMI).

Her science-backed method of Neural Rewiring has successfully guided thousands of clients toward happier, more productive, and more resilient lives.