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OCD worsens because each compulsion rewires the CSTC loop through Hebbian co-firing, shifting it from ventral to dorsal striatum. See...
Read article : Why OCD Gets Worse Over Time: The Neural EscalationIn OCD the orbitofrontal cortex overvalues threat, tagging ordinary thoughts as catastrophic. See how lateral OFC hyperactivity drives the compulsion...
Read article : Orbitofrontal Cortex and OCD: The Overvaluation LoopSSRIs help only 40 to 70 percent of people with OCD. The reason is a multi-circuit CSTC pattern, not low...
Read article : OCD and Serotonin Imbalance: Why SSRIs Fail for Half
